Hyaluronic Acid: Hyaluronic Acid (HA) can be characterized as Nature’s Healing Molecule. In joints, HA is the major constituent of synovial fluid, the joint’s lubricant. HA degradation is common in inflamed joints and other tissues. HA aids in the migration of cells, creation of new tissue, reduces inflammation and inflammatory processes associated with pain and supports the vascular system and the immune system. HA therapies have been approved for Osteoarthritis, as adhesion prevention and for ocular formulations. HA is naturally non-allergenic and non-immunogenic.
PFI’s source of HA is non-animal and is therefore free of any possible contamination. PFI specifies a particular Molecular Weight range for this product, as we have found that the desired properties for HA are dependent on this value.
HA and its properties are a subject of major interest for many major research institutes. One such entity, the Matrix Biology Institute has published studies on the oral administration of HA in animals (e.g. equine studies). A modest daily dose of HA in fully mature race horses significantly aided their joint health.
SOD/Gliadin (GliSodin): SOD stands for SuperOxide Dismutase, Nature’s most powerful ant-oxidant enzyme system. This formulation is the only one that has been verified to survive the trip through the digestive system and to be absorbed in the small intestine. Absorption of SOD/Gliadin up-regulates the body’s own ability to synthesize SOD. As a consequence the body’s anti-oxidant system shifts into High Gear. Inflammation due to oxidation and degradation is reduced and the entire immune/inflammation system is brought into balance. Every tissue in the body is protected and allowed to bring itself back into a state of homeostasis.
SOD/Gliadin up-regulates the body’s defenses against foreign invaders and reduces runaway inflammation associated with tissue degradation. It supports the cardio-vascular system, especially under conditions of stress and oxidative damage. It supports the body’s ability to metabolize and eliminate toxins, such as lactic acid and alcohol, so that potential damage is mitigated.
Because much of the pain felt that is associated with chronic conditions may be associated with oxidative damage, SOD/Gliadin is a key ingredient in protecting all tissues and functions.
Acetyl-11-Keto-Beta-Boswellic Acid (11-Keto ABA): 11-Keto ABA is a naturally occurring constituent of the Boswellia plant found through out Asia. 11-Keto ABA has been shown to be chemically active in the inhibition of an enzyme called 5-Lipoxygenase which is involved in the pathway leading to inflammatory degradation of cartilage and other tissues. 11-Keto ABA has also been shown to inhibit other enzymes involved in runaway inflammatory responses such as Matrix Metalloproteinases.
In Human and Animal genetic studies, 11-Keto ABA application inhibited genes that are involved it the production and activation of major inflammatory molecules such as TNF-alpha. This molecule has been identified as a major constituent in the progression of Rheumatoid Arthritis, asthma and psoriasis. In Human and Animal clinical studies, 11-Keto ABA performed better than a placebo in subjects with Osteo and Rheumatoid Arthritis, asthma and Inflammatory Bowel Disease (e.g. Crohn’s Disease).
Extensive safety studies have been performed on 11-Keto ABA. It has been pronounced safe at doses many times greater than are necessary for therapeutic effects.
11-Keto ABA opens a whole new era of natural supplements with potent chemical activity in key areas of chronic conditions associated with pain and tissue destruction. 11-Keto ABA is a new weapon in the fight against inflammation.
We would like to group the ingredients Hyaluronic Acid, SOD/Gliadin, and 11-Keto ABA in a group under the name HD•5 (as HD•5 logo).
MSM: MSM is a simple small molecule that occurs in nature in many fruits and other foods. It is however destroyed by food processing. Contrary to many published statements, MSM is NOT a source of “Sulfur”, but is an Oxidized-Organo-Sulfur compound. In several large human trials, MSM has been shown to repair and preserve cartilage and reduce pain and inflammation associated with Rheumatoid and Osteo-Arthritis. Among the medical community, MSM is perhaps best noted for its ability to relieve pain and discomfort associated with auto-immune joint problems. In fact, it is used by Rheumatologists often in conjunction with other disease modifying drugs.
MSM is safe even at high doses (>1000mg per day) and no side effects have been documented. It is absorbed readily when taken orally.
Glucosamine Sulfate: Glucosamine is also a simple small organic molecule that serves in the body as a building block for cartilage and other related connective tissues and extracellular Matrix materials. It can be found in its native form or in the so-called N-acylated form (NAG). Despite its simplicity, Glucosamine has been shown in human trials to reduce the loss of cartilage due to Arthritis and related conditions. In addition, it was found to reduce the progression of joint disease.
Glucosamine is safe at high doses (>1000mg per day) and is absorbed readily when taken orally. It is fully compatible with other medications. Do not use if allergic to shellfish.
Chondroitin Sulfate: Chondroitin is a bio-polymer that is manufactured by the body as a major constituent of cartilage. Its unique molecular properties ensure the structural integrity of cartilage and its shock absorbing qualities. When combined with HA, they form a potent combination of mechanical stability and lubrications. These large biopolymers, such as HA and Chondroitin, readily survive the digestive system and are easily absorbed. In two large human trials, Chondroitin has shown significant improvement from pain and inflammation due to arthritic conditions as well as improved joint function. In fact, some people in the study were able to decrease the amount of Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) they were taking. This situation further adds to Gastro-intestinal stability.
Chondroitin is safe at high doses (>1000mg per day).
Colostrum: Colostrum is nature's perfect first food. It is the pre-milk substance produced from the mother’s breasts of all mammals during the first 24 hours of lactation. From 24-48 hours this is called transitional milk. After 48 hours milk is defined. Colostrum supplies immune and growth factors and a perfect combination of vitamins and minerals to insure the health, vitality and growth of the newborn.
Medical Research has shown that the most important immune and growth factors for humans can be provided from bovine colostrum. It is biologically transferable to all mammals including man and is much higher in immune factors than human mother's colostrum.
Laboratory analyses of both immune and growth factors from bovine colostrum indicate that they are identical to those found in human colostrum except for the fact that the levels of these factors are significantly higher in the bovine version. Bovine colostrum is actually 40 times richer in immune factors like IgF-1, IgG, and TgF A and B than human colostrum. For example, human colostrum contains 2% of IgG (immuno-globulin G) while cow colostrum contains 86% of IgG, the most important of the immuno-globulins found in the body.
In this formula it helps correct leaky gut syndrome which is one of the leading causes of Rheumatism. Multiple studies have proven its effectiveness for Rheumatoid Arthiritis, inflammation (which is the root cause of pain), wound healing, athletic performance, and more. With over 2000 clinical and scientific studies it is the most studied nutrient in the world.
Colostrum has been added to the OrthoTrex formulation for its many documented benefits. It is safe at high doses and is a potent ingredient in this powerful formula.